While attempting to use Host Profiles with IBM hardware, you may receive an error when trying to apply a host profile "An error has occurred".
This error is actually due to the IMM – “InBand” communications device presenting itself as an Ethernet over USB device to the operating system as a legit network card.

In VMware it presents as vusb0 as per the pic below:

In this particular case it created issues with the Host profiles (the VMware Host profiles would partially implement and then error out with totally meaningless errors which were quite hard to troubleshoot).

It also swaps the PCI addressing order around during / after the install phase, so when we selected the first PCI addressed NIC to be the Service Console Uplink during the intial install,  after the reboot at end of ESX install the vusb swaps itself in as the primary SC NIC (based on PCI address). Though this doesnt always happen, it depends on the hardware model. An example is on HS22 blades the host profile issue occurs but the PCI swapping does not occur.

We resolved both issues by setting the following value in the IMM settings in the BIOS:

Commands on USB Interface = Disabled